Are you struggling with the relentless itch and discomfort of atopic dermatitis? If you’re seeking treatment that genuinely works, you’re not alone. Atopic dermatitis, more commonly known as eczema, affects up to 20% of children and 10% of adults. For you and the millions of others living with the condition, there’s a game-changing treatment that offers a way to attain the clear, calm skin you’ve been longing for. Discover this and more about biologics, a cutting-edge therapy with the potential to revolutionize how we manage atopic dermatitis.

Understanding Atopic Dermatitis and Biologics

Atopic dermatitis, a chronic inflammatory skin condition, affects millions across the United States, with a significant portion residing in Florida. It manifests as red, itchy, and inflamed skin, often leading to discomfort and reduced quality of life. Traditional treatments may provide relief, but some fall short of managing symptoms effectively. This is where biologics step in, offering a promising solution for those struggling with eczema.

How Do Biologics Target Eczema?

Biologics represent a groundbreaking approach to treating atopic dermatitis, targeting specific immune system components responsible for triggering inflammation. Here are some commonly prescribed biologics for eczema treatment:

• Dupilumab (Dupixent)
• This biologic targets interleukin-4 receptor alpha (IL-4R⍺), a protein involved in the inflammatory response.
• By inhibiting IL-4R⍺, Dupixent helps reduce inflammation and itchiness associated with atopic dermatitis.

• Tralokinumab (Adtralza)
• Adtralza targets interleukin-13 (IL-13), another key player in the immune response cascade leading to eczema symptoms.
• By blocking IL-13, this biologic helps alleviate inflammation and improve skin barrier function.

• Lebrikizumab
• This biologic targets interleukin-13 (IL-13), similar to Tralokinumab, aiming to interrupt the inflammatory process.
• By inhibiting IL-13, Lebrikizumab helps mitigate the immune system’s overactive response, thereby reducing eczema symptoms.

How are Biologics for Atopic Dermatitis Administered?

Biologics, like Dupilumab, are injected under the skin. For adults and adolescents aged 12 years and older, they are typically administered once every two weeks. However, they are given once every four weeks for younger children between 6 months and 11 years.

• Self-Administration

After receiving proper training from an allergist, patients or their caregivers can administer dupilumab at home. Adults can self-inject, while supervision is necessary for children aged 12 and above. For younger children, a caregiver should handle the injection.

• Injection Sites

It is recommended to inject into the thigh or abdomen (except for the area around the navel). If someone else is administering the injection, they can use the upper arm as an alternative site. They should rotate the injection site with each dose and steer clear of tender, damaged, or scarred skin.

• Storage Instructions

Store biologics in a refrigerator at temperatures between 2–8°C. Before injecting, let the medication sit out for a bit. For a 300 mg dose, please wait at least 45 minutes; for 200 mg, wait 30 minutes until it reaches room temperature. Once out of the fridge, the pens and syringes can remain at room temperature (up to 25°C) for up to 14 days but cannot be refrigerated again once they reach room temperature. Avoid shaking the pen or syringe.

• Missed Dose

If you happen to miss a dose, don’t panic. Consult your allergist or nurse for guidance. The timing of your next dose will depend on how long it’s been since your last one. If you accidentally take too much or administer the dose too early, reach out to your healthcare provider for assistance.

What Sets Biologics Apart from Other Treatments?